桑俊 博士

讲师，硕士生导师

工作学习经历

2010-2014   山西中医药大学，中药学院，中药学学士

2014-2017   陕西师范大学，生命科学学院，中药学硕士

2018-2022   中山大学，药学院，生药学博士

2023-至今   昆明理工大学生命科学与技术学院，讲师、硕士生导师

研究领域

中药药效物质及药理学研究：通过高通量筛选发现中药中抗肿瘤、脂肪肝、抑郁的天然小分子化合物，结合药理学和化学生物学手段阐明其药效机制和作用靶点。

开设的课程

《药剂学》、《新药研究与开发》

代表性论文

1. Yu-Song Song, Chen-Kai Liu, Wu-Shuang Jiang, Jue Liu, Yue-Xuan Liu, Fei-Xue Yu, Gao Liu, Tian-Rui Xu*, Jun Sang*. Targeting GRB2 with Polyphyllin H overcomes PIKFYVE inhibitor resistance in bladder cancer by blocking Akt–SREBP1–SCD1 pathway. Phytomedicine, 154:158011, 2026.

2. Ya-Nan Fei, Ming-Yang Hao, Jia-Qiang Liu, Yin-Song Dong, Hui-Ning Zou, Xiao-Xi Guo, Su An, Jun Sang*, Tian-Rui Xu*. Ginsenoside Rg1, a natural lysosomal enhancer, alleviates Parkinson’s disease pathology via cathepsin D-dependent regulation of α-synuclein homeostasis. Phytotherapy Research, 40:5357–5373, 2026.

3. Wu-Shuang Jiang, Fei-Xue Yu, Yue-Xuan Liu, Yu-Song Song, Chen-Kai Liu, Jue Liu, Gao Liu, Tian-Rui Xu*, Jun Sang*, Celastrol synergizes with MEK1 inhibitor nedometinib to overcome resistance in bladder cancer via dual suppression of CDK1/CDC5L and feedback-activated Akt/STAT3. Biochemical Pharmacology, 245:117629, 2026.

4. Yue-Xuan Liu, Yu-Song Song, Chen-Kai Liu, Jue Liu, Fei-Xue Yu, Wu-Shuang Jiang, Gao Liu, Tian-Rui Xu*, Jun Sang*, Paris polyphylla Smith var. yunnanensis-derived saponins potentiate the antitumor activity of GPX4 inhibitors. Journal of Ethnopharmacology, 357: 120890, 2026.

5. Jue Liu, Yue-Xuan Liu, Yu-Song Song, Chen-Kai Liu, Fei-Xue Yu, Gao Liu, Tian-Rui Xu*, Jun Sang*, Targeting GRB2-Akt-SREBP1 signaling axis by saponins from Paris polyphylla Smith var. yunnanensis (Franch.) Hand.-Mazz to overcome cisplatin resistance in bladder cancer. Journal of Ethnopharmacology, 354: 120502, 2026.

6. Chen-Kai Liu, Jue Liu, Gao Liu, Yu-Song Song, Xiu-Yu Yang, Hong-Lei Gao, Cheng Xiang, Jie Sang*, Tian-Rui Xu*, and Jun Sang*, Clitoria ternatea L. flower–derived anthocyanins and flavonoids inhibit bladder cancer growth by suppressing SREBP1 pathway–mediated fatty acid synthesis, Acta Biochimica et Biophysica Sinica, 57: 770–781, 2025.

7. Jun Sang*, Chen-Kai Liu, Jue Liu, Guan-Cong Luo, Wei-Ji Zheng, Ya Bai, De-Yun Jiang, Jiang-Ni Pu, Su An, Tian-Rui Xu*, Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells, Biochemical Pharmacology, 223: 116194, 2024.

主持项目

1. 国家自然科学基金地区项目，32万元，进行中，主持（2027.01-2030.12）

2. 昆明理工大学高层次人才引进项目，80万元，进行中，主持（2023.03-2031.07）

3. 云南省自然科学基金面上项目，10万元，进行中，主持（2024.03-2027.02）

联系方式

地址：云南省昆明市呈贡区昆明理工大学大学生命科学与技术学院细胞信号传导研究室（650500）

电话：17338361783

E-mail：junsang@foxmail.com