1.团队负责人：
2.团队成员：
3.研究方向：
方向一：益生菌益生性质、益生机理及其调控机制
研究内容：开展自然发酵乳的微生物生态和功能菌种的发酵机制，开发功能性发酵乳的工业化生产技术；发酵法制备生物活性肽，在分子、细胞和动物水平研究其生物活性的生物学机制。
方向二：微生物环境适应性机制及其酶的开发应用
研究内容：利用多组学、反向遗传学、生物化学等多学科技术手段研究不同环境胁迫下红酵母中油脂、多不饱和脂肪酸、类胡萝卜素、胞外多糖等多种天然生物活性物质合成与环境胁迫适应性之间的关系，揭示不同环境胁迫条件下这些生物活性物质合成调节的信号转导途径及其调节机制，进一步结合代谢网络模型构建和代谢工程策略构建高效生产不同生物活性物质的代谢工程菌株。
方向三：人体微生物组
研究内容：聚焦微生物组在女性生殖健康（不孕症、HPV感染）及癌症（甲状腺癌、宫颈癌、结直肠癌）中的作用机制，探究分娩方式（自然分娩/剖腹产）对新生儿肠道菌群定植及早期健康的影响，为疾病防治和母婴健康提供新策略。
方向四：功能性发酵食品研发及其活性机制的研究
研究内容：开发具备降尿酸、降血压作用的发酵乳制品，调节睡眠的益生菌豆浆豆豉和益生性锋产品，以及探究功能食品发挥益生效用的分子机制。
4.团队成果：
（1）承担项目
近5年主持国家自然科学基5项，省部级基金10项。
国家基金地区项目，32460229，不同CUPP分类来源S8角蛋白酶的底物特异性及其机制研究，2025/01-2028/12，在研，国家级
国家基金地区项目，32360566，热胁迫下麦芽糖促进粘红酵母胞外多糖合成的分子调控机制研究，2024/01-2027/12，在研，国家级
国家基金地区项目，32260579，植物乳杆菌中pABA生物合成相关基因的发掘及对叶酸生物合成的分子调控机理初探，2023/01-2026/12，在研，国家级
国家基金地区项目，32260249，白腐菌HSF调控木质纤维素降解酶的合成机制及转化性能分析，2023/01-2026/12，在研，国家级
国家基金地区项目，32260863，肠道菌介导调节蜂王性成熟的分子机制研究，2023/01-2026/12，在研，国家级
云南省“兴滇英才支持计划”青年人才项目，KKXX202426053，基于酶的挖掘改造及构效机制开发云南特色植物微生物蛋白，2024/01-2028/12，在研，省部级
科技厅面上项目，202401CF070142，人体尿道生殖道古菌菌群的研究，，2024/03-2027/02，在研，省部级
科技厅面上项目，202401AT070390，嗜热角蛋白降解菌耐受还原剂的适应性进化及其机制解析，2024/03-2027/02，在研，省部级
科技厅昆明理工大学“双一流”创建联合专项面上项目，202201BE070001-024，202201BE070001/024，嗜热微生物高效降解角蛋白的机理及应用研究，2022/10-2025/09，在研，省部级
云南省乡村振兴科技专项科技特派员项目，云财教〔2022〕167号，云南省乡村振兴科技特派员-郭军，2022/01-2024/12，在研，省部级
云南省三区人才项目，云财教【2022】158号，2022年度云南省三区人才-郭军，2022/06-2023/05，在研，省部级
科技厅面上项目，202201AT070191无菌蜂王模型的构建及功能评价，郭军，2022/06-2025/05，在研，省部级
云南省三区人才项目，国科农函〔2021〕25号，2021年云南省“三区”科技人才-郭军，2021/08-2022/08，在研，省部级
科技厅面上项目，202101AT070139，植物乳杆菌在德昂族自然发酵酸茶中的抗氧化机制研究，2021/04-2024/03，验收，省部级
科技厅面上项目，202101AT070070，Lactobacillus plantarum RB/4菌株对展青霉素降解的机制研究，2021/04-2024/03，验收，省部级
（2）发表论文专著
近5年发表SCI论文60余篇。
1. Li JL, Li WL, Zhang J, Pang YT, Xiong J, Wu P, Wei BR, Li XJ, Huang Q, Tang QH, Zhao CH, Wang Q, Liu ZL, Chen Y, Dong ZX, Zhao YZ, Guo J. Seasonal dynamics of the microbiota and nutritional composition in bee bread from Apis cerana and Apis mellifera colonies. Food Res Int. 2024 8;190:113905.
2. Zhao SH, Zhang SM, Yang JW, Liu CJ, Zeng XQ, Zhang YL, Chen SQ, Zhao ZM, Xia YX, Li XR, Shang Y. Preliminary study on the active substances and cellular pathways of lactic acid bacteria for colorectal cancer treatment. J Cancer. 2024 7 16;15(15):4902-4921.
3. Wang T, Xiong YG, Si TZ, Yan JP, Li XR, Liu CJ, Yang E. Effects of priming glycosyltransferase genes cps 2E and cps 4E on the exopolysaccharide biosynthesis byLactiplantibacillus plantarumYM-4-3 strain. Int J Biol Macromol. 2024 6;269(Pt 1):131813.
4. Huang X, Fan J, Guo C, Chen Y, Qiu J, Zhang Q. Integrated Transcriptomics and Metabolomics Analysis Reveal the Regulatory Mechanisms Underlying Sodium Butyrate-Induced Carotenoid Biosynthesis in Rhodotorula glutinis. J Fungi (Basel). 2024 4; 27;10(5):320.
5. Dong YH, Luo YH, Liu CJ, Huang WY, Feng L, Zou XY, Zhou JY, Li XR. Changes in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection. J Transl Med. 2024 2 1;22(1):125.
6. Zhang S, Hu X, Zhang C, Ju Y, Liu X, Wei Y. Dopamine alters phage morphology to exert an anti-infection effect. Front Microbiol. 2023 11 9;14:1272447.
7. Tang Q, Li W, Wang Z, Dong Z, Li X, Li J, Huang Q, Cao Z, Gong W, Zhao Y, Wang M, Guo J. Gut microbiome helps honeybee (Apis mellifera) resist the stress of toxic nectar plant (Bidens pilosa) exposure: Evidence for survival and immunity. Environ Microbiol. 2023 10;25(10):2020-2031.
8. Li WL, Huang Q, Li JL, Wu P, Wei B, Li XJ, Tang QH, Dong ZX, Xiong J, Tang H, Zhang J, Zhao CH, Cao Z, Chen Y, Zhao WZ, Wang K, Guo J. Gut microbiota-driven regulation of queen bee ovarian metabolism. Microbiol Spectr. 2023 9 26;11(5):e0214523.
9. Zou H, Ding Y, Shang J, Ma C, Li J, Yang Y, Cui X, Zhang J, Ji G, Wei Y. Isolation, characterization, and genomic analysis of a novel bacteriophage MA9V-1 infectingChryseobacterium indologenes: a pathogen of Panax notoginseng root rot. Front Microbiol. 2023 9 14;14:1251211.
10. Zhang S, Shi C, Liu C, Zou X, Gong F, Li X. Dynamic Analysis of the Bacterial Community and Determination of Antioxidant Capacity during the Fermentation of Sour Tea. Fermentation. 2023; 9(2):161.
11. He M, Guo R, Chen G, Xiong C, Yang X, Wei Y, Chen Y, Qiu J, Zhang Q. Comprehensive Response ofRhodosporidium kratochvilovaeto Glucose Starvation: A Transcriptomics-Based Analysis. Microorganisms. 2023 8 27;11(9):2168.
12. Feng Y, Zeng S, Yan J, Li K, Xu H. Genome-Wide Analysis and Expression of MYC Family Genes in Tomato and the Functional Identification of slmyc1 in Response to Salt and Drought Stress. Agronomy. 2023; 13(3):757.
13. Zou, L., Su, J., Xu, T., Ji, X., Wang, T., Chen, Y., Jiang, Y., Qiu, J., Zhang, Q. & Hu, B. Untargeted metabolomics revealing changes in aroma substances in flue-cured tobacco. Open Chemistry, 2023 4;21(1), 20220326.
14. Li Y, Xiong L, Yu H, Xiang Y, Wei Y, Zhang Q, Ji X. Biogeochemical sulfur cycling of virus auxiliary metabolic genes involved in Napahai plateau wetland. Environ Sci Pollut Res Int. 2023 3;30(15):44430-44438.
15. Xie L, Cheng L, Wei Y. Mitomycin C enhanced the antitumor efficacy of Rocaglamide in colorectal cancer. Pathol Res Pract. 2023 3;243:154350.
16. Zhai J, Liang Y, Zeng S, Yan J, Li K, Xu H. Overexpression of tomato glutathione reductase (SlGR) in transgenic tobacco enhances salt tolerance involving the S-nitrosylation of GR. Plant Physiol Biochem. 2023 3;196:497-506.
17. Gao H, Feng GD, Feng Z, Yao Q, Li J, Deng X, Li X, Zhu H. Pseudomonas citri sp. nov., a potential novel plant growth promoting bacterium isolated from rhizosphere soil of citrus. Antonie Van Leeuwenhoek. 2023 3;116(3):281-289.
18. Dong YH, Fu Z, Zhang NN, Shao JY, Shen J, Yang E, Sun SY, Zhao ZM, Xiao A, Liu CJ, Li XR. Urogenital tract and rectal microbiota composition and its influence on reproductive outcomes in infertile patients. Front Microbiol. 2023 2,10;14:1051437.
19. Tang QH, Li WL, Wang JP, Li XJ, Li D, Cao Z, Huang Q, Li JL, Zhang J, Wang ZW, Guo J, Li JL. Effects of spinetoram and glyphosate on physiological biomarkers and gut microbes inBombus terrestris. Front Physiol. 2023 1, 9;13:1054742.
20. Dong, Y., Zhai, J., Yan, J., Li, K., & Xu, H. Physiological and transcriptomic responses of antioxidant system and nitrogen metabolism in tomato seedlings treated with nitrogen starvation and re-supply. The Journal of Horticultural Science and Biotechnology, 2022; 98(1), 57–71.
21. Guo R, Liu T, Guo C, Chen G, Fan J, Zhang Q. Carotenoid biosynthesis is associated with low-temperature adaptation in Rhodosporidium kratochvilovae. BMC Microbiol. 2022 12, 24;22(1):319.
22. Wu YR, Dong YH, Liu CJ, Tang XD, Zhang NN, Shen J, Wu Z, Li XR, Shao JY. Microbiological composition of follicular fluid in patients undergoing IVF and its association with infertility. Am J Reprod Immunol. 2023 3;89(3):e13652.
23. Zhu G, Tan W, Xie L, Ma C, Chen X, Zhang S, Wei Y. Mechanisms underlying the inhibitory effects of Cd2+ on prodigiosin synthesis in Serratia marcescens KMR-3. J Inorg Biochem. 2022 11;236:111978.
24. Qiao S , Feng Y , Yan J , Li H, Xu H. Overexpression of tomato SlTpx improves salt stress tolerance in transgenic tobacco plants by scavenging H2O2.Plant Cell, Tissue and Organ Culture (PCTOC), 2022, 151(2):321-333.
25. Zhu G, Xie L, Tan W, Ma C, Wei Y. Cd2+ tolerance and removal mechanisms of Serratia marcescens KMR-3. J Biotechnol. 2022 11, 20;359:65-74.
26. He M, Yang X, Liu T, Zhang X, Ji X, Wei Y, Zhang Q. Hybrid histidine kinase HisK2301 modulates carotenoid production to counteract cold-induced oxidative stress in Rhodosporidium kratochvilovae YM25235 under low temperature. Antonie Van Leeuwenhoek. 2022 12;115(12):1393-1404.
27. Dong ZX, Tang QH, Li WL, Wang ZW, Li XJ, Fu CM, Li D, Qian K, Tian WL, Guo J. Honeybee (Apis mellifera) resistance to deltamethrin exposure by Modulating the gut microbiota and improving immunity. Environ Pollut. 2022 12, 1;314:120340.
28. Cai S B , Wu G , Dong Z X , Lin L B, Guo J, Zhang Q L.Colonization dynamics of the gut flora in western honey bee workers within 7-day post-emergence.Apidologie, 2022 8;53, 44.
29.于航,徐志伟,魏云林,等.病毒辅助代谢基因的研究进展.微生物学报, 2022, 62(8):2879-2892.
30. Liu CJ, Xiao WY, Fang JF, Dong YH, Ye KF, He MP, Wang YS, Li X, Zhao ZM, Yuan T, Zhao T, He CY, Zhang SM, Yang E, Wu XM, Li XR. Genital Microbiota of Women From Six Ethnic Groups With and Without Human Papillomavirus Infection in Shangri-La, China. Front Cell Infect Microbiol. 2022 2, 8;12:935068.
31. Chen W, Zhang X, Li S, Cui J, Yang X, Zhang Q. The MAP-Kinase HOG1 Controls Cold Adaptation in Rhodosporidium kratochvilovae by Promoting Biosynthesis of Polyunsaturated Fatty Acids and Glycerol. Curr Microbiol. 2022 7, 14;79(9):253.
32. Qu Y, Luo Y, Yang X, Zhang Y, Yang E, Xu H, He Y, Chagan I, Yan J. Highly Efficient Biotransformation of Phenolic Glycosides Using a Recombinant β-Glucosidase From White Rot Fungus Trametes trogii. Front Microbiol. 2022 5, 18;13:762502.
33. Shan Y, Shang J, Zhang D, Cui Y, Wang Y, Zhu J, Ma Y, Song P, Qin K, Ji X, Wei Y, Wu L .Cloning, Expression and Biochemical Characterization of the Recombinant α-amylase from Bacillus subtilis YX48.Current Proteomics, 2022 2;19(3)218:225.
34. Zhai J, Qi Q, Wang M, Yan J, Li K, Xu H. Overexpression of tomato thioredoxin h (SlTrxh) enhances excess nitrate stress tolerance in transgenic tobacco interacting with SlPrx protein. Plant Sci. 2022 2;315:111137.
35. Xiang Y, Ma C, Yin S, Song F, Qin K, Ding Y, Yang X, Song P, Ji X, Wei Y. Phage therapy for refractory periapical periodontitis caused by Enterococcus faecalis in vitro and in vivo. Appl Microbiol Biotechnol. 2022 3;106(5-6):2121-2131.
36. Xie L, Ji X, Zhang Q, Wei Y. Curcumin combined with photodynamic therapy, promising therapies for the treatment of cancer. Biomed Pharmacother. 2022 2;146:112567.
37. Gao J, Liu N, Zhang X, Yang E, Song Y, Zhang J, Han Q. Utilizing the DNA Aptamer to Determine Lethal α-Amanitin in Mushroom Samples and Urine by Magnetic Bead-ELISA (MELISA). Molecules. 2022 1, 15;27(2):538.
38. Zhang C, Zheng , Bai , Luo Q, Shang , Xie L , Wei Y . Novel Carbon Dots Based on Pseudomonas aeruginosa for High Selectivity Detection of Cr6+ and Bioimaging Both in vitro and in vivo. Nano, 2022;17 (01).
39.Ding Y, Zhang D, Zhao X, Tan W, Zheng X, Zhang Q, Ji X, Wei Y. Autoinducer-2-mediated quorum-sensing system resists T4 phage infection in Escherichia coli. J Basic Microbiol. 2021 12;61(12):1113-1123.
40. Xie L, Zhu G, Shang J, Chen X, Zhang C, Ji X, Zhang Q, Wei Y. An overview on the biological activity and anti-cancer mechanism of lovastatin. Cell Signal. 2021 11;87:110122.
41. Zhang C, Qin K, Zheng X, Luo Q, Zhang Q, Ji X, Wei Y. Synthesis of carbon dots with antiphage activity using caffeic acid. Anal Methods. 2021 11, 11;13(43):5165-5172.
42. Liu CJ, Chen SQ, Zhang SY, Wang JL, Tang XD, Yang KX, Li XR. The comparison of microbial communities in thyroid tissues from thyroid carcinoma patients. J Microbiol. 2021 11,;59(11):988-1001.
43. Jie, W.，Ping, L.，Shengting, Z.，Wanwan, L.，Xiuling, J.，Jing, L.,et al., .A Novel GLP-1R/fHCS Method to Determine the Bioactivity of Glucagon- Like Peptide 1(GLP-1) Analogous Drugs In Vitro. Current Pharmaceutical Analysis 2021;17(9), 1197-1205
44. Tang Q , Xiong J , Wang J , Cao Z , Liao S , Xiao Y , Tian W , Guo Jun.Queen bee larva consumption improves sleep disorder and regulates gut microbiota in mice with PCPA-induced insomnia. Food Bioscience, 2021(43-):43.
45. Ba Y , Zhai J , Yan J , Li K , Xu H .H2S improves growth of tomato seedlings involving the MAPK signaling. Scientia Horticulturae, 2021, 288:110366.
46.徐志伟,陈学梅,魏云林,等.基于宏基因组分析纳帕海高原湿地微生物及其碳氮代谢多样性.生物工程学报, 2021 9,37(09).
47. Guo R, He M, Zhang X, Ji X, Wei Y, Zhang QL, Zhang Q. Genome-Wide Transcriptional Changes of Rhodosporidium kratochvilovae at Low Temperature. Front Microbiol. 2021 9, 16;12:727105.
48. Zhang Y, Dong Z, Luo Y, Yang E, Xu H, Chagan I, Yan J. The Manganese Peroxidase Gene Family of Trametes trogii: Gene Identification and Expression Patterns Using Various Metal Ions under Different Culture Conditions. Microorganisms. 2021 12, 16;9(12):2595.
49. Tang QH, Miao CH, Chen YF, Dong ZX, Cao Z, Liao SQ, Wang JX, Wang ZW, Guo J. The composition of bacteria in gut and beebread of stingless bees (Apidae: Meliponini) from tropics Yunnan, China. Antonie Van Leeuwenhoek. 2021 8;114(8):1293-1305.
50. Yang E, Fan L, Jiang Y, Doucette C, Fillmore S, Han Q. Effect of natural antimicrobial agent (MicroGARD) combined with edible coating (NatureSeal) treatment on fresh-cut butternut squash. J Food Sci. 2021 5;86(5):2035-2044.
51. Liu L, Qin K, Yin S, Zheng X, Li H, Yan H, Song P, Ji X, Zhang Q, Wei Y, Zhao L. Bifunctional Carbon Dots Derived From an Anaerobic Bacterium of Porphyromonas gingivalis for Selective Detection of Fe3+ and Bioimaging. Photochem Photobiol. 2021 5;97(3):574-581.
52. Dong ZX, Chen YF, Li HY, Tang QH, Guo J. The Succession of the Gut Microbiota in Insects: A Dynamic Alteration of the Gut Microbiota During the Whole Life Cycle of Honey Bees (Apis cerana). Front Microbiol. 2021 4, 14;12:513962.
53．Zhang Y, Wu Y, Yang X, Yang E, Xu H, Chen Y, Chagan I, Yan J. Alternative Splicing of Heat Shock Transcription Factor 2 Regulates the Expression of Laccase Gene Family in Response to Copper in Trametes trogii. Appl Environ Microbiol. 2021 4, 15;87(8):e00055-21.
54. Luo Z W , Jiang Y H , Lin L B , Deng X Y, Zhang Q, Zhang Q L.Genome-wide differential expression analysis explores antibacterial molecular mechanisms of zebrafish intestine upon pathogenic Streptococcus agalactiae challenge.Aquaculture Reports, 2021, 19:100639.
55. Luo Q , Qin K , Liu F , Zheng X , Ding Y , Zhang C , Xu M , Liu X , Wei Y . Carbon dots derived from kanamycin sulfate with antibacterial activity and selectivity for Cr6+ detection. Analyst. 2021 3, 21;146(6):1965-1972.
56. Liu L, Zhang S, Zheng X, Li H, Chen Q, Qin K, Ding Y, Wei Y. Carbon dots derived from Fusobacterium nucleatum for intracellular determination of Fe3+ and bioimaging both in vitro and in vivo. Anal Methods. 2021 3, 11;13(9):1121-1131.
57. Zheng X , Qin K , He L , Ding Y , Luo Q , Zhang C , Cui X , Tan Y , Li L , Wei Y . Novel fluorescent nitrogen-doped carbon dots derived from Panax notoginseng for bioimaging and high selectivity detection of Cr6. Analyst. 2021 2, 7;146(3):911-919.
58. Ji X , Wang S , Luo Y , Yuan X , Wei Y , Zhang Q , Qin K , Tu Y.Green synthesis of weissella-derived fluorescence carbon dots for microbial staining, cell imaging and dual sensing of vitamin B12 and hexavalent chromium.Dyes and Pigments, 2021, 184:108818.
59. Ding Y , Tan W , Zheng X , Ji X , Song P , Bao L , Zhang C , Shang J , Qin K , Wei Y . Serratia marcescens-derived fluorescent carbon dots as a platform toward multi-mode bioimaging and detection of p-nitrophenol. Analyst. 2021 1, 21;146(2):683-690.
60. Guo L, Xu W, Li C, Guo Y, Yamei, Chagan I. Comparative study of physicochemical composition and microbial community of Khoormog, Chigee, and Airag, traditionally fermented dairy products from Xilin Gol in China. Food Sci Nutr. 2021 1 19;9(3):1564-1573.
61. Cui Z, Xu Z, Wei Y, Zhang Q, Qin K, Ji X. Characterization and Genome Analysis of a Novel Mu-like Phage VW-6B Isolated from the Napahai Plateau Wetland of China. Curr Microbiol. 2021 1;78(1):150-158.
62. Tu Y , Wang S , Yuan X , Xiang Y , Qin K , Wei Y , Zhang Q; ChenX , Ji X.Facile hydrothermal synthesis of nitrogen, phosphorus-doped fluorescent carbon dots for live/dead bacterial differentiation, cell imaging and two nitrophenols detection.Dyes and Pigments, 2021, 184(000).
（3）所获知识产权和技术标准
近5年授权专利32项。
1.一种驼乳源小分子肽及其应用，伊日布斯，王嘉鑫，严金平，2024/11，ZL 202310089954.3
2.无刺蜂越冬饲喂装置和蜂箱，郭军，李万里，王凯，旦真. 2024/08，ZL 202420071413.8
3.一种过氧化物酶体增值因子基因RkPEX11及其用途，张琦，马红俊，魏云林，陈媛，邱婧雯，2024/04，ZL 202310090676.3
4.一种乙酸渗透酶A基因RkAcpa及其应用，张琦，范晶碟，熊超，魏云林，陈媛，邱婧雯，2024/04，ZL 202211334167.2
5.一种泛酸激酶基因RkPank及其应用，张琦，熊超，魏云林，邱婧雯，陈媛，2024/04，ZL 202211333662.1
6.一种乙酰CoA合成酶基因RkACS2及其应用，张琦，黄小岚，杨晓霞，陈媛，邱婧雯，2024/04，ZL202310537742.7
7.一种NADH激酶基因RkNADHK1及其应用，张琦，甘雨萱，陈汝艺，邱婧雯，陈媛，2024/03，ZL202310533180.9
8.马乳酪蛋白小分子肽在制备二肽基肽酶Ⅳ抑制剂中的用途，伊日布斯，陈亚辉，高杰，陈子衡，成超，王嘉鑫，严金平，2024/02，ZL 202210004446.6
9.一种葡萄糖-6-磷酸脱氢酶基因RkZWF1及其应用，张琦，陈汝艺，魏云林，邱婧雯，陈媛，2024/03，ZL 202211340770.1
10.一种红冬孢酵母启动子及其应用，张琦，郭锐，2023/09，ZL 202210174477.6
11.一种乙醛脱氢酶基因RKALDH及其应用，张琦，倪金梅，郭彩娜，魏云林，季秀玲，2023/07，ZL 202210090376.0
12.一种马乳源小分子肽及其应用，伊日布斯，陈子衡，陈亚辉，成超，王嘉鑫，严金平，2023/07，ZL 202111481405.8
13.3-酮脂酰辅酶A硫解酶基因RKACAA1-2及其应用，张琦，杨晓霞，陈功水，2023/04，ZL 202110895024.8
14.一种甲羟戊酸激酶基因RKMK及其应用，张琦，郭彩娜，魏云林，2023/04，ZL 202210003665.2
15.3-酮脂酰-CoA硫解酶基因RkACAA1-1及其应用，张琦，陈功水，魏云林，季秀玲，2023/03，ZL 202110895025.2
16.一种咖啡酸碳点在抗噬菌体中的应用，魏云林，张春婷，秦堃豪，郑晓丹，丁亚芳，季秀玲，张琦，2022/07，ZL 202110641050.8
17.乙酰CoA合成酶基因RKACS1及其应用，张琦，邹玲，陈波，2023/04，ZL 202110619574.7
18.一种植物乳杆菌的基因在叶酸生物生成中的应用，柳陈坚，赵志敏，李晓然，2023/04，ZL 202110251431.5
19.焦磷酸基因酶的用途，柳陈坚，陈斯谦，李晓然，2023/03，ZL 202110246865.6
20.一株产虾青素的红冬孢酵母基因工程菌株，张琦，崔志城，肖兴明，郭彩娜，魏云林，林连兵，季秀玲，2022/05，ZL 202010368747.8
21.一种酰基辅酶A氧化酶2基因RKACOX2及其应用，张琦，刘韬，和美霞，魏云林，季秀玲，2022/03，ZL 202011322537.1
22.一种粪肠球菌噬菌体及其分离、纯化、富集和应用，魏云林，向盈盈，李文玉，宋飞，季秀玲，秦堃豪，张东芳，2022/02，ZL 201910333177.6
23.3-羟基-3-甲基戊二酸单酰辅酶A还原酶基因RKHMGR及其应用，张琦，和美霞，魏云林，林连兵，季秀玲，2021/11，ZL 201911070771.7
24.HMG-CoA合成酶基因RKHMGCS及其应用，张琦，陈波，魏云林，季秀玲，2021/10，ZL 201910240926.0
25.乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用，张琦，张晓庆，魏云林，林连兵，季秀玲，2021/10，ZL 201910147204.0
26.一种蜂类毒理学和营养学实验用饲喂盒，郭军，唐启河，曹喆，陈奕霏，2021/09，ZL 202023235827.0
27.一种鉴定毛栓孔菌S0301中同核体菌株的方法，严金平，伊日布斯，杨恩，2021/08，ZL 201810175037.6
28.一个苹果酸脱氢酶基因CIMDH1及其重组表达载体，张琦，季秀玲，魏云林，林连兵，2021/07，ZL 201810492054.2
29.锌指转录因子基因RkMsn4的用途，张琦，季秀玲，魏云林，林连兵，2021/06，ZL 201810492044.9
30.一株粪肠球菌及其应用，魏云林，向盈盈，季秀玲，宋飞，杨向红，于鸿滨，周静，秦堃豪，秦榕，2021/04，ZL 201910741574.7
31.一株基因工程菌乳酸乳球菌及其应用，罗义勇，2021/03，ZL 201710944929.3
32.一种β-葡萄糖苷酶Ttbgl3及其应用，严金平，张宇，曲媛，罗媛，李雪杰，杨旭磊，伊日布斯，2022/01，ZL 202011343650.8
（4）团队曾获科研、教学奖励
云南省特殊生境噬菌体库的建立及在难治性根尖周炎治疗中的应用，向盈盈,宋飞,季秀玲,魏云林,夏志刚,段开文，2024/04，云南省科技进步奖三等奖
创新本科教学管理模式，科教融合构建生命科学人才培养新高地,林连兵、夏雪山、李云军、徐天瑞、宋玉竹、陈媛、李晓然、祝扬扬、高传柱、向诚, 2023/03,云南省教学成果奖二等奖
